Thursday, October 16, 2014

Diseases Associated with the Golgi Apparatus


Alzheimer’s disease is linked to the Golgi body in that, as the disease progresses the Golgi apparatus becomes fragmented, rendering it incapable of modifying and transporting proteins and lipids like it normally does. Batten Disease is also linked to the Golgi because the source of the disease, the batten disease protein, localizes around the Golgi and researchers believe there is a connection between the two. Batten disease is an inherited and fatal neurodegenerative disease. The Inclusion Cell or I-Cell disease is caused by defective phosphotransferase, an enzyme involved in adding phosphate groups to tell the protein where to go. Without it, proteins that should be going to the lysosome (which function as catabolic enzymes for the normal breakdown of substances in lysosomes) are excreted from the cell and the lysosome is unable to break down cell waste.


Peripheral blood lymphocyte appearance in a case of I-cell disease

22 comments:

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